Type of ACNE

1.  Acne Vulgaris

Acne vulgaris is the medical name for common acne -- the presence of blackheads, whiteheads, and other types of pimples on the skin. The most common spots for breakouts are the face, chest, shoulders, and back. Although mild acne may improve with over-the-counter treatments, more severe forms should be treated by a dermatologist.

2. Comedones

A comedo, or basic acne lesion, is a hair follicle that has become clogged with oil and dead skin cells. Comedones (the plural of comedo) can develop into bumps called whiteheads and blackheads. Products that may trigger comedones are called "comedogenic." Makeup labeled "noncomedogenic" is less likely to clog pores and contribute to acne.

3. Blackheads

Blackheads are comedones that are open at the surface of the skin. They are filled with excess oil and dead skin cells. It's not dirt that causes the comedone to turn black. The oil's reaction to air causes the black color. Blackheads can frequently be treated with over-the-counter medications.

4. Whiteheads

Comedones that stay closed at the surface of the skin are called whiteheads. This happens when oil and skin cells prevent a clogged hair follicle from opening. Many of the same over-the-counter medicines that treat blackheads are also effective against whiteheads.

5. Papules

Papules are comedones that become inflamed, forming small red or pink bumps on the skin. This type of pimple may be sensitive to the touch. Picking or squeezing can make the inflammation worse and may lead to scarring. A large number of papules may indicate moderate to severe acne.

6. Pustules

Pustules are another kind of inflamed pimple. They resemble a whitehead with a red ring around the bump. The bump is typically filled with white or yellow pus. Avoid picking or squeezing pustules. Picking can cause scars or dark spots to develop on the skin.

7.Nodules

Nodules are large, inflamed bumps that feel firm to the touch. They develop deep within the skin and are often painful. Nodules should be treated by a dermatologist. Over-the-counter treatments may not be powerful enough to clear them up, but prescription drugs can be effective.

8.Cysts

Cysts are large, pus-filled lesions that look similar to boils. Like nodules, cysts can be painful and should be treated by a dermatologist. People who develop nodules and cysts are usually considered to have a more severe form of acne.

9. Mild Acne

Acne falls into the "mild" category if you have fewer than 20 whiteheads or blackheads, fewer than 15 inflamed bumps, or fewer than 30 total lesions. Mild acne is usually treated with over-the-counter topical medicine. It may take up to eight weeks to see a significant improvement.

10. Moderate Acne

If you have 20 to 100 whiteheads or blackheads, 15 to 50 inflamed bumps, or 30 to 125 total lesions, your acne is considered moderate. Dermatologists usually recommend prescription medication for moderate to severe acne. It may take several weeks to notice an improvement, and your acne may appear to get worse before it gets better.

11. Severe Nodulocystic Acne

People with severe nodulocystic acne have multiple inflamed cysts and nodules. The acne may turn deep red or purple. It often leaves scars. Prompt treatment by a dermatologist can minimize scarring. In some cases, a doctor may inject corticosteroids directly into nodules and cysts to reduce the size and painful inflammation.

12. Acne Conglobata

Acne conglobata is one of the most severe forms of acne. It involves many inflamed nodules that are connected under the skin to other nodules. It can affect the neck, chest, arms, and buttocks. It often leaves scars. This type of acne is more common in men and is sometimes caused by taking steroids or testosterone. Timely treatment by a dermatologist is essential.

13. Acne Mechanica

Acne mechanica is caused by heat, friction, and pressure against the skin, often the result of wearing sports gear such as a helmet or baseball cap. It is sometimes called "sports-induced acne" because it occurs frequently in athletes. Preventive measures include wearing an absorbent material under sports equipment and showering immediately after activity.

14. Topical Therapy

Topical therapy is acne medication that is applied directly to the skin, like gels or creams. Over-the-counter topical products can often help mild acne. They may contain ingredients like benzoyl peroxide, resorcinol, salicylic acid, or sulfur. Prescription products such as antimicrobial or retinoid creams can treat mild to moderately severe acne. These can be prescribed alone or in combination with other ingredients.

15. Systemic Therapy

Systemic therapy refers to acne medication that is taken by mouth. Antibiotics like tetracycline, minocycline, doxycycline, or erythromycin may treat moderate to severe acne by targeting bacteria and reducing inflammation. Other systemic therapies include oral contraceptives, which can reduce acne in some women, spironolactone, an anti-androgen hormone pill, and isotretinoin (high-dose prescription vitamin A). Isotretinoin is used only in certain severe, cystic acne cases, or in cases where other treatments don't work. A course of isotretinoin treatment requires regular appointments with your dermatologist.

Source: http://www.webmd.com/

PAPAYA LEAF EXTRACT in Malaysia for Dengue

Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever

The study was conducted to investigate the platelet increasing property of Carica papaya leaves juice (CPLJ) in patients with dengue fever (DF). An open labeled randomized controlled trial was carried out on 228 patients with DF and dengue haemorrhagic fever (DHF). Approximately half the patients received the juice, for 3 consecutive days while the others remained as controls and received the standard management. Their full blood count was monitored 8 hours for 48 hours. Gene expression studies were conducted on the ALOX 12 and PTAFR genes. 

The mean increase in platelet counts were compared in both groups using repeated measure ANCOVA. There was a significant increase in mean platelet count observed in the intervention group () but not in the control group 40 hours since the first dose of CPLJ. Comparison of mean platelet count between intervention and control group showed that mean platelet count in intervention group was significantly higher than control group after 40 and 48 hours of admission (). The ALOX 12 (FC  =  15.00) and PTAFR (FC  =  13.42) genes were highly expressed among those on the juice. It was concluded that CPLJ does significantly increase the platelet count in patients with DF and DHF.

Refer below research paper for more information,

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614241/

http://www.hindawi.com/journals/ecam/2013/616737/

http://www.clinicalresearch.my/cure-for-dengue-a-palatable-papayas-bitter-pill/

Papaya leaf juice safe for dengue patients, says govt

http://www.freemalaysiatoday.com/category/nation/2016/01/30/papaya-leaf-juice-safe-for-dengue-patients-says-govt/

Product available in Malayia

BIOVERSA MONO PAPAYA LEAF EXTRACT CAPSULE

50grams of C. papaya leaves of the the sekaki variant can speed up (if not cure) dengue fever. A study done by IMR Malaysia involved giving freshly extracted papaya leaf juice (tastes bitter as hell) to Grade 1 and Grade 2 Dengue patients. These patients showed significantly raised PTAFR genes(13.42 fold) compared to those receiving standard treatment. This is in turn translated as a potential for improving outcome in Dengue patients, because increased platelet count usually means that the patient is getting better.

Composition:

Each Vegecap (300mg) contains:

Folium Carica Papaya--------------------250mg

Indication:

Traditionally used for General Well Being.

Direction:

Adult: Take 2 capsules with meal once a day

This is a Traditional Medicine. Please consult your doctor/pharmacist before taking this product.

Warning: Not recommended for & contraindicated in pregnancy and breastfeeding women.

Price: RM75 per box of 60s

Mimimum order: 2 box 

Email: pharmacistsharing@yahoo.com
Whatapps: 012-7334511

Bergamonte™ in Malaysia

 

The History of Bergamot
 
Bergamot (Citrus Bergamia Risso) is a citrus plant that grows almost exclusively in the narrow coastal Calabria region in Southern Italy, due to sensitivity to the weather and soil conditions. Bergamot juice was traditionally recognized by the local population as a remedy for supporting healthy cholesterol level and cardiovascular health. The medicinal use of bergamot, forgotten for decades, is now being rediscovered.

The juice and albedo of bergamot has a unique profile of flavonoid and glycosides, such as neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin have been shown to be beneficial in animal models of atherosclerosis, while neoeriocitrin and rutin have been found to exhibit a strong capacity to prevent LDL from oxidation. Importantly, bergamot juice is rich in brutieridine and melitidine with an ability to inhibit HMG-CoA reductase.

Standardized, Clinically Tested
Bergamonte^® contains bioactive compounds of extract of the juice and albedo of citrus bergamia risso, standardized to > 30% polyphenolic flavanoids consisting of Naringin, Neohesperidin, Neoeriocitrin, 1% Melitidine, and 2% Brutelidine. Bergamonte^® is produced using patented extraction technology through collaborative works of various Universities and research institutions in Italy. These flavanoids are clinically proven to help maintain healthy cholesterol level^†, healthy blood glucose level, increase HDL-cholesterol, and promoting healthy weight management.
Benefits of Bergamonte^®

• Cardiovascular Health
• Supports Healthy Cholesterol^†
• Supports Healthy Blood Sugar
• Healthy Weight Loss

Citrus Bergamot Differs From C. Aurantium...
Citrus Bergamot differs from C. Aurantium as Citrus Bergamot does not contain Synepherine, N-methyltyramine, and octopamine, which have been shown in research to constrict arteries, increase blood pressure, increase heart rate, cause
heart-rhythm disorders, heart attack, and stroke.
Citrus Bergamot contains Melitidine and Brutelidine which is absent in C. Aurantuim. Research has shown that these compounds significantly reduce total cholesterol, LDL, Triglycerides^†, blood glucose levels, while increasing HDL.

Melitidine and Brutieridine

A published research article in the Journal of Natural Products 2009 showed that bergamot juice contained novel compounds with statin like principles, having the 3-hydroxy3-methylglutaric acid (HMG) found to the naringin (melitidine) and neohesperidin (brutieridine).
These novel compounds interfere with the natural synthesis of the cholesterol pathway in the human body: The HMG-CoA substrate interferes with the synthesis of the mevalonate acid, blocking the cholesterol production.

                                                                 

Superior Full-Spectrum Antioxidant ORAC Potency

Mode of Action

• Inhibiting HMG-CoA Reductase
• Inhibiting Phosphodiesterases PDEs
• 'Activating' AMPK

Efficacy Findings from Clinical Trials
In an unpublished human clinical trial involving 192 patients, the following are the result after patients consumed 100ml of Citrus Bergamot juice for 30 days.

Hypolipemic and Hypoglycemic Activity of Bergamot Polyphenolic Fraction
Fitoterapia 82 (Nov 2011) 309–316
237 patients with hyperlipemia, hypercholesterolemic (HC, cLDL, low cHDL), mixed dyslipidemic (HC and TG), or metabolic syndrome (HC, HT, and HG) were taking either placebo, 500mg, 1000mg.

The effect of Bergamot Polyphenolic Fraction (500 and 1000 mg/daily) on reactive vasodilatation in patients suffering from isolated (HC) or mixed hyperlipidemia (HC/HT) and associated hyperglycemia (HC/HT /HG).Bergamot Polyphenolic Fraction reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, it  inhibited HMG-CoA reductase activity and enhances reactive vasodilation.

Supports healthy cholesterol level^†, increase LOX-1 expression and Protein Kinase B phosphorylation
International Journal of Cardiology, 2013
In this open-label, parallel group, placebo-controlled study, 77 patients were randomly assigned either placebo, Rosuvastatin, Bergamot Polyphenolic Fraction or combination of Bergamot Polyphenolic Fraction with Rosuvastatin for 30 days.

Both doses of rosuvastatin and Bergamot Polyphenolic Fraction help support healthy cholesterol level^† and reduce urinary mevalonate compared to control group. The benefits are associated with significant reductions of biomarkers used for detecting oxidative vascular damage, including malondialdehyde, oxyLDL receptor LOX-1 and phosphoPKB.
Effects on LDL Small Dense Particles, Metabolic Biomarkers, and Liver Function
Advances in Biological Chemistry, 2014, 4, 129-137
107 patients with metabolic syndrome and non fatty liver disease were given either placebo or 650 mg of Bergamot Polyphenolic Fraction twice a day for 120 days. Bergamot Polyphenolic Fraction group showed significant reduction in fasting plasma glucose, rotal cholesterol, LDL cholesterol, triglycerides, and increase of HDL cholesterol. Bergamot Polyphenolic Fraction decrease IDL particles by 51%, increase large LDL by 38%, decrease small LDL by 35%, and 20% increase of total HDL particles. Hepatorenal index was significantly reduced by 46%, accompanied by reduction of hepatic ultrosonographic pattern of steatosis by 99%. This suggests Bergamot Polyphenolic Fraction improves both liver function and inflammation as confirmed by reduction of TNF-α and CRP.

Product Comparison

^† Already within the normal range


Retail Price: RM98 per bottle of 100s

Available in all Cosway store,

ID for Special Price : MY 517431A

RM85 per bottle of 100s
RM299 for 5 bottle of 100s



References

1. Ross Walker, Elzbieta Janda and Vincenzo Mollace. The Use of Bergamot-derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action. Cardiac Health and Polyphenols. Chp 84, Pg 1085-1103, 2014
2. Micaela Gliozzi, Ross Walker, Elzbjeta Janda, Vincenzo Mollace. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol, LOX-1 expression and Protein Kinase B phosphorylation in patients with hyperlipidemia. International Journal of Cardiology Dec 2013, 170(2):140-5
3. Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia 82 (2011) 309–316
4. Celia C, Trapasso E, Locatelli M, Navarra M, Ventura CA, Wolfram J, Carafa M, Morittu VM, Britti D, Di Marzio L.. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surf B Biointerfaces. 2013 Dec 1;112:548-53
5. Delle Monache S, Sanità P, Trapasso E, Ursino MR, Dugo P, Russo M, Ferlazzo N, Calapai G, Angelucci A, Navarra M. Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice. PLoS One. 2013 Apr 16;8(4)
6. Kang P, Suh SH, Min SS, Seol GH. The essential oil of Citrus bergamia Risso induces vasorelaxation of the mouse aorta by activating K(+) channels and inhibiting Ca(2+) influx. J Pharm Pharmacol. 2013 May;65(5):745-9
7. Leopoldini M, Malaj N, Toscano M, Sindona G, Russo N. On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme. J Agric Food Chem. 2010 Oct 13;58(19):10768-73
8. Di Donna L, De Luca G, Mazzotti F, Napoli A, Salerno R, Taverna D, Sindona G. Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. J Nat Prod. 2009 Jul;72(7):1352-4
9. Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E. The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation. J Cardiovasc Pharmacol Ther. 2008 Jun;13(2):120-9
10. Natalizia Miceli, Maria Mondello, Maria Mondorte, Vasileios Sdrafkakis, Paola Dugo, Maria Crupi. Hypolipidemic effects of bergamot juice in rats Fed a Hypercholesterolemic Diet. J. Agric. Food Chem., Vol. 55, No. 26, 2007

 

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Get your man to go for a health screening?

A simple survey carried out recently among readers of The Star Online revealed that only 25% of women found it easy to get their men to go for a health screening.

The online survey, carried out in conjunction with the Fight For Your Man campaign by Janssen Malaysia, resolves to increase the number of men going for medical check-ups in the country by creating awareness, calling for preventive measures and encouraging each of us to play a key role in our men’s health.

The results suggested that men can be unaware or uncooperative about their personal well-being and the need for regular health screening. Only 18 % of respondents said that their men had undergone prostate cancer screening.

On the brighter side, men seemed to be more open to conversation about their health – 34 % of respondents said that their men shared their personal health concerns in depth with them, while 29% of the respondents said that their men shared personal health concerns, but with limited access to the details.

Also, while only 21 % of respondents said that they were well aware of prostate cancer and its impact on their family, 73 % of respondents were keen to know more about prostate cancer – generally signalling a positive flag for prostate cancer awareness.

The Fight For Your Man campaign calls for each of us to play our part by committing to protect the men we care about by empowering ourselves with knowledge of the disease, encouraging men to lead a healthy lifestyle and attending timely check-ups.

Looking back at the history of men’s role in the family as sole breadwinner, they were once defined by their strength, courage, and their financial contribution to the household. Any illness otherwise would be perceived as a weakness.

In modern times, this mentality still lingers among many men. Being concerned about health is often associated with feminine values, and as a result, men only start worrying about their health conditions when visible symptoms started to kick in. Most of the time, it is already too late.

Prostate cancer is the second most common cancer to affect men globally, and in Malaysia, it is the fourth most commonly diagnosed cancer among men . Like most cancers, prostate cancer comes with little to no warning signs, in very early phase, which is why it is so important for men to get screened regularly.

The prostate screening for men is simple and can be done at most clinics. A blood sample will be drawn and tested for the level of prostate specific antigens, commonly referred to as PSA.

Men with a PSA level of four and below can be more or less assured that they do not have any prostate-related problems, although there are rare exceptions. A high level of PSA can be a sign of cancer.

Prostate cancer can affect men as young as 40 years, and the risk increases with age. It is advisable, therefore, that men get tested annually from the age of 40 onwards, at their nearest clinic.

---

 This article is brought to you in conjunction with the Fight For Your Man campaign by Janssen Malaysia.

Goat Milk VS Cow Milk

Q. What are the benefits of feeding my baby goat's milk? I've heard it can improve digestion, especially in infants over one year old. Is this true?

A. I frequently advise goat's milk for patients in my pediatric practice, especially those who have digestive problems or who are unable to tolerate cow's milk. In infants who show an intolerance to cow's milk—symptoms of this can include colicky abdominal pain, bloating, diarrhea and facial rashes—parents often report that many of these allergic reactions disappear or greatly improve after switching to goat's milk. 

Here are the reasons why goat's milk is more easily digested and less allergenic than cow's milk in many infants

less allergenic proteins

The protein clumps that are formed by the action of the stomach acids on the protein are called curds. The softer the curd, the quicker it passes through the stomach. Goat's milk protein forms a softer curd, which makes it easier to digest. This could be an advantage for infants who spit up a lot or who have gastroesophageal reflux (GER).

 Goat's milk contains only trace amounts of the allergenic protein found in cow's milk—alpha-S1 casein. However, goat's milk and cow's milk both contain another type of allergenic protein, beta-lactoglobulin, which is why some infants who are allergic to cow's milk may also be allergic to goat's milk

a more digestible fat

The fat globules in goat's milk are easier to digest because they contain a higher proportion of short and medium-chain fatty acids. It's a biochemical quirk that allows the intestinal enzymes to digest the fat easier. Cow's milk contains more of the longer-chain fatty acids that require more work for the intestines to digest

slightly less lactose

While both cow's milk and goat's milk contain the sugar lactose, goat's milk contains slightly less (4.1 percent versus 4.7 percent in cow's milk). It's possible that this is a slight advantage for infants who are lactose intolerant

cautions about goat's milk:

The vitamin and mineral content of goat's milk and cow's milk are fairly similar, though goat's milk contains a bit more calcium, vitamin B6, vitamin A, potassium, niacin, copper and the antioxidant selenium. On the other hand, cow's milk contains more vitamin B12 and much more folic acid. Since goat's milk contains less than ten percent of the amount of folic acid contained in cow's milk, it must be supplemented with folic acid. For this reason, be sure you get a goat's milk that is supplemented with folic acid, which the best brands usually are (If you're unsure of a good brand, I recommend Meyenberg goat milk to my patients.).

Also, be sure to buy goat's milk that's certified "free of bovine growth hormone (BGH) and antibiotics." Generally, the American Academy of Pediatrics does not recommend the use of goat's or cow's milk products in infants under one year because they can cause intestinal irritation and anemia. Infants under one year of age who are allergic to cow's milk-based formulas, soy formulas or hypoallergenic formulas are sometimes put on goat's milk formula, but only with consultation from baby's doctor or a pediatric nutritionist.

Source: http://www.parenting.com

Your brain is a powerful fat-burning tool

You don't need to be Charles Xavier to use your brain to burn fat.

Study suggests that your brain could coach your body to burn fat, says research.

The brain could be a powerful fat burning tool, say scientists at Monash University in Melbourne who discovered that two naturally occurring hormones interact to convert energy-storing white fat into energy-burning, “good” brown fat.

“Turning white fat into brown fat is a very exciting new approach to developing weight loss agents,” says lead author Professor Tony Tiganis from the Department of Biochemistry and Molecular Biology. “Eventually, we think we may be able to help people lose weight by targeting these two enzymes.”

One of the enzymes, leptin, is an appetite suppressant that’s generated in fat cells and the other is insulin, which comes from the pancreas when levels of glucose in the blood start to rise.

Tiganis’ research shows that the two hormones act together and persuade a group of neurons – called proopiomelanocortin (POMC) neurons – in the brain to convert the fat from white to brown, thereby igniting the fat-burning process.

“These hormones give the brain a comprehensive picture of the fatness of the body,” says Tiganis. “Because leptin is produced by fat cells, it measures the level of existing fat reserves – the more fat, the more leptin. Whereas insulin provides a measure of future fat reserves because glucose levels rise when we eat.”

If all this has you wondering why you can’t just think your way skinny, chances are enzymes called phosphatases that inhibit the actions of leptin and insulin could be working against you.

Tiganis’ team found that when phosphatases were reduced, more brown fat was created and more fat was burned.

Don’t give up your diet or cancel your gym membership just yet!

Tiganis says any potential therapy based on his team’s research is still a long way off.

Brown fat cells, also called adipocytes, occur most densely around the neck and shoulders, according to the researchers, whose study was published in the journal Cell.

That white adipocytes can be converted to brown has been suggested by several studies revealing a variety of methods to do so.

For example, a study at Maastricht University Medical Center in the Netherlands says it’s possible to create brown fat by keeping your surroundings cool, while another published in the journal Cell Press indicates that Mirabegron, a drug normally used to treat an overactive bladder, could also do the job. – AFP Relaxnews